FARMAKOGENETİĞİN ANTİDEPRESANLARIN KLİNİK KULLANIMI ÜZERİNE ETKİSİ

The interest on personalized medicine encourages researches pharmacogenetics. promotion of new analytical combinations in extensive drug development and also with the progression technologies for human gene cloning resulted a great In last years genetical sciences influenced Personalized includes areas such as stratified precision these terms are closely related Moderate response rates difference effect individuals focus pharmacogenetics psychopharmacology area antidepressants. It is considered that genetic factors may contribute %50 antidepressant response. Additionally properties patient pharmacokinetics pharmacodynamics antidepressants therefore change an increase side effects be seen. genes which codes serotonin transporter, 5-HTTLPR SLC6A4 commonly investigated they thought to main reasons responses. Also activities CYP 2D6 2C19 stable concentration leves plasma. These variations contributing levels lead this review, we focused different classes drugs selective serotonine reuptake inhibitors, serotonin-noradrenaline tricyclic mono-amine oxidase inhibitors. We have compiled pharmacogenetic studies